Thalamic cholinergic innervation is spared in Alzheimer disease compared to parkinsonian disorders
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چکیده
منابع مشابه
Challenging the cholinergic hypothesis in Alzheimer disease.
THE IDEA THAT SOME OF THE SYMPTOMS OF ALZHEIMER disease are due to a deficiency of the neurotransmitter acetylcholine in the brain first surfaced in 1976 and 1977. Several groups of investigators reported that the activity of enzymes involved in the synthesis (choline acetyltransferase [ChAT]) and degradation (acetylcholinesterase [AChE]) of acetylcholine were markedly reduced in activity in au...
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The medical profession has been generally very slow to acknowledge the importance of sleep medicine and sleep research. Disorders of sleep are related to anxiety, many mental and neurodegenerative diseases, cardiovascular and respiratory disorders, and obesity. Our knowledge of the neural substrates of sleep/wake states and sleep-related behavior disorders regulation in health and the diseases,...
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BACKGROUND Pathology reports have shown that cholinergic forebrain neuronal losses in parkinsonian dementia (PDem) are equal to or greater than those in Alzheimer disease (AD). We hypothesized that patients with PDem would have cholinergic deficits that were similar to or greater than those of patients with AD. OBJECTIVE To determine in vivo cortical acetylcholinesterase (AChE) activity in he...
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Parkinson’s disease (PD) is a relatively common neurological disorder in the elderly. However, only 76% of patients considered clinically to have PD are confirmed to have PD after postmortem examination (Hughes et al., 1993). The most common atypical form of parkinsonism is multiple system atrophy (MSA) (Hughes et al., 1994). MSA is clinically characterized by a combination of parkinsonian, aut...
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ژورنال
عنوان ژورنال: Neuroscience Letters
سال: 2012
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2012.02.083